I'm probably the only person that would notice this. I was watching episode 11 (The Devil's Lube) of season 6 of Two and a Half Men. In the episode Charlie was in the car with Alan & talking on the phone with his doctors office. All the while he's holding his (1st gen) iPhone upside down. He finishes his conversation. Talks to Alan a little more then calls Rose. He's holding the phone correctly, then the camera zooms in & he's holding it upside down again.
Yes, I realize this doesn't have anything to do with tech. Except the fact that Charlie was using a 1st gen. iPhone albeit incorrectly.